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Reen Wu, Ph.D.

University of California, Davis # of Grants: 4

Grants

Role of thioredoxin in ETS-induced pulmonary airway injury 1998 (Cycle 7) $425,665
Pulmonary Disease Research Project Awards

Pathogenesis of Smoke-Induced Injury in Airway Epithelium 1994 (Cycle 3) $431,266
Pulmonary Disease Research Project Awards

Mechanism of smoke-induced MUC5B gene expression 2001 (Cycle 10) $392,117
Pulmonary Disease Research Project Awards

Epigenetic Regulation of Airway MUC gene expression by smoke 2007 (Cycle 16) $419,528
Pulmonary Disease Research Project Awards
Publications

Inhibition of epidermal growth factor-like growth factor secretion in tracheobronchial epithelial cells
Periodical: Cancer Research Index Medicus:
Authors: Miller L, Cheng LZ, Wu R ART
Yr: 1993 Vol: 53 Nbr: 11 Abs: Pg: 2527-2533

Expression of a squamous cell marker, the spr1 gene is posttranscriptionally down-regulated by retinol in airway epithelium
Periodical: Journal of Cellular Physiology Index Medicus:
Authors: An G, Tesfaigzi J, Carlson DM, Wu R ART
Yr: 1993 Vol: 157 Nbr: 3 Abs: Pg: 562-568

Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: An G, Tesfaigzi J, Chuu YJ, Wu R ART
Yr: 1993 Vol: 268 Nbr: 15 Abs: Pg: 10977-10982

Control of keratin gene expression by vitamin A in tracheobronchial epithelial cells
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Huang TH, Ann DK, Zhang YJ, Chang AT, Crabb JW, Wu R ART
Yr: 1994 Vol: 10 Nbr: 2 Abs: Pg: 192-201

A PCR differential screening method for rapid isolation of clones from a cDNA library
Periodical: Biotechniques Index Medicus:
Authors: Luo G, An G, Wu R ART
Yr: 1994 Vol: 16 Nbr: 4 Abs: Pg: 672-675

Expression of MUC-2 gene is down-regulated by vitamin A at the transcriptional level in vitro in tracheobronchial epithelial cells
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: An G, Lui G, Wu R ART
Yr: 1994 Vol: 10 Nbr: 5 Abs: Pg: 546-551

In vitro exposure of tracheobronchial epithelial cells and of tracheal explants to ozone
Periodical: Toxicology Index Medicus:
Authors: Tarkington BK, Wu R, Sun WM, Nikula J, Wilson DW, Last J ART
Yr: 1994 Vol: 88 Nbr: 1-3 Abs: Pg: 51-68

Coordinated expression of 45kd protein synthesis and ozone toxicity in human bronchial epithelial cell line
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Sun WM, Wu R, Last J ART
Yr: 1994 Vol: 10 Nbr: 6 Abs: Pg: 673-682

Effects of exposure to environmental tobacco smoke on a human tracheobronchial epithelial cell line
Periodical: Toxicology Index Medicus:
Authors: Sun WM, Wu R, Last JA ART
Yr: 1995 Vol: 100 Nbr: Abs: Pg: 163-174

Glutathione S-transferase in tracheobronchial epithelium: differential expression and regulation by vitamin A and collagen substratum
Periodical: American Journal of Physiology Index Medicus:
Authors: Reddy SP-M, Tu D, Wu R ART
Yr: 1995 Vol: 269 Nbr: Abs: Pg: 473-481

Two nuclear proteins in tracheal epithelial cells are recognized by antibodies specific to a squamous differentiation marker, spr1
Periodical: Journal of Cellular Physiology Index Medicus:
Authors: Tesfaigzi J, An G, Wu R, Carlson DM ART
Yr: 1995 Vol: 164 Nbr: 3 Abs: Pg: 571-578

Cellular expression of transforming growth factor-a and its mRNA in the developing rabbit lung
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Edward LA, Voit MM, Miller MA, Wu R, Plopper CG ART
Yr: 1995 Vol: Nbr: Abs: Pg:

Down regulation of TGF-a gene expression in conducting airway epithelium
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Miller LA, Zhao YH, Wu R ART
Yr: 1996 Vol: 97 Nbr: Abs: Pg: 1429-1435

Isolation and characterization of nucleolin gene expresion in airway epithelium by a palindromic primer-based mRNA differential display method
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Reddy SPM, An G, Di YP, Zhao YH, Wu R ART
Yr: 1996 Vol: Nbr: Abs: Pg:

Expression of human squamous cell differentiation marker, sprl, is dependent on jun and tre motifs
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Reddy SPM, Chuu YJ, Lao PN, Donn J, Ann DK, Wu R ART
Yr: 1995 Vol: 270 Nbr: Abs: Pg: 26451-26459

DNA damage in human respiratory tract epithelial cells: damage by gas phase cigarette smoke apparently involves attack by reactive nitrogen species in addition to oxygen radicals
Periodical: FEBS Journal Index Medicus:
Authors: Spencer JPE, Jenner A, Chmiel K, Aruoma OI, Cross CE, Wu R, Halliwell B ART
Yr: 1995 Vol: 375 Nbr: Abs: Pg: 179-182

DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells
Periodical: FEBS Journal Index Medicus:
Authors: Spencer JPE, Jenner A, Chmiel K, Aruoma OI, Cross CE, Wu R, Halliwell B ART
Yr: 1995 Vol: 374 Nbr: Abs: Pg: 233-236

Structure and organization of the gene encoding a mouse small proline-rich proteins, mSPRR1A and 1B
Periodical: Gene Index Medicus:
Authors: Reddy SPM, Konkin T, Wu R ART
Yr: 1998 Vol: 224 Nbr: Abs: Pg: 59-66

Differential expression of stress proteins in non-human primate lung and conducting airway after ozone exposure
Periodical: American Journal of Physiology Index Medicus:
Authors: Wu R, Zhao YH, Plopper CG, et al ART
Yr: 1999 Vol: 277 Nbr: Abs: Pg: L511-L522

A novel mechanism of retinoic acid-enhanced interleukin-8 gene expression in airway epithelium
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Chang MMJ, Harper R, Hyde DM, Wu R ART
Yr: 2000 Vol: 22 Nbr: Abs: Pg: 502-510

Distinct roles for amino- and carboxyl-terminal sequences of SPRR1 protein in the formation of cross-linked envelopes of conducting airway epithelial cells
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Deng J, Pan R, Wu R ART
Yr: 2000 Vol: 275 Nbr: Abs: Pg: 5739-5747

Induction of cell cornification and enhanced squamous cell marker SPRR1 gene expression by phorbol ester are regulated by different signaling pathways in human conducting airway epithelial cells
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Deng J, Chen Y, Wu R ART
Yr: 2000 Vol: 22 Nbr: Abs: Pg: 597-603

Mechanism of dexamethasone mediated interleukin-8 gene suppression in cultured airway epithelial cells
Periodical: American Journal of Physiology Index Medicus:
Authors: Chang MMJ, Juarez M, Hyde DM, Wu R ART
Yr: 2001 Vol: 280 Nbr: Abs: Pg: L107-L115

Characterization of human MUC5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region
Periodical: American Journal of Respiratory and Critical Care Medicine Index Medicus:
Authors: Chen Y, Zhao YH, Di P, Wu R ART
Yr: 0 Vol: Nbr: Abs: Pg:

Oxidative stress disrupts glucocordicoid hormone-dependent transcription of the amiloride sensitive epithelial sodium channel a-subunit in lung epithelial cells through ERK-dependent and thioredoxin-sensitive pathways
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Wang HC, Zentner MD, Deng HT, et al ART
Yr: 2000 Vol: 275 Nbr: Abs: Pg: 8600-8609

Phorbol ester-induced expression of airway squamous cell diffeeerentiation marker, SPRR1B, gene is regulated by PKC/Ras/Mekk1/Mkk1-dependent/AP-1 signal transduction pathway
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Vuong H, Patterson T, Shapiro P, et al ART
Yr: 2000 Vol: 275 Nbr: Abs: Pg: 32250-32259

Allergic asthma induced in rhesus monkeys by hosue dust mite
Periodical: American Journal of Pathology Index Medicus:
Authors: Schelegle ES, Gershwin LJ, Miller LA, et al ART
Yr: 2001 Vol: 158 Nbr: Abs: Pg: 333-341

Fishing for inflammatory cytokine-induced genes with an old trick
Periodical: American Journal of Physiology Index Medicus:
Authors: Wu R, Chen Y ART
Yr: 2001 Vol: 280 Nbr: Abs: Pg: L839-L840

Characterization of a novel airway epithelial cell-specific-chain alcohol dehydrogenase/reductase gene whose expression is upregulated by retinoids and is involved in the metabolism of retinol
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Cherly MS, Di YP, Hayden L, Zhao YH, Satre MA, Wu R ART
Yr: 0 Vol: Nbr: Abs: Pg:

Regulatin of thioredoxin gene expression by vitamin A in human airway epithelial cells.
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Chang WH, Reddy SP-M, Di YPP, Yoneda K, Harper R, and Wu R ART
Yr: 2002 Vol: 26 Nbr: Abs: Pg: 627-635

Development of high-density DNA microarray membrane for profiling smoke-and hydrogen peroxide-induced genes in a human bronchial epithelial cell line.
Periodical: American Journal of Respiratory and Critical Care Medicine Index Medicus:
Authors: Yoneda K, Peck K, Chang MMJ, Chmiel K, Sher, YP, Chen J, Yang PC, Chen Y, and Wu R ART
Yr: 2001 Vol: 164 Nbr: Abs: Pg: S85-S89

Molecular cloning, and characterization of a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts, SPURT.
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Di YP, Zhao YH, Harper R, Wu R ART
Yr: 2003 Vol: 278 Nbr: Abs: Pg: 1165-1173

Stimulation of airway mucin gene expression by IL-17 through IL-6 paracrine/autocrine loop.
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R ART
Yr: 2003 Vol: 278 Nbr: Abs: Pg: 17036-17043

Genome-wide search of novel gel-forming mucin genes and identification of MUC19/Muc19 as a new glandular tissue-specific mucin gene.
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Chen Y, Zhao YH, Kalaslavadi TJ, Hamati E, Nehrke K, Wu R, et al ART
Yr: 2003 Vol: 30 Nbr: Abs: Pg: 155 - 165

Application of high density DNA microarray to study smoke-and hydrogen peroxide-induced injury and repair in human brochial epithelial cells.
Periodical: Journal of American Society of Nephrology Index Medicus:
Authors: Yonda K, Chang M,, Chmiel K, Chen Y, Wu R ART
Yr: 2003 Vol: 14 Nbr: Abs: Pg: S284 - S289

An unusual participation for four RARE-like motifs in retinoid-stimulated transciption of human thioredoxin gene.
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Chang V, Reddy S.P-M, Zhou JW, Wu R ART
Yr: 2002 Vol: 26 Nbr: Abs: Pg: 627 - 635

Interlukin-17 markedly up-regulates beta defensin 2 expression in human airway epithelium via JAK and NF-kB pathways.
Periodical: Journal of Immunology Index Medicus:
Authors: Kao C-Y R, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R ART
Yr: 2004 Vol: 173 Nbr: Abs: Pg: 3482 - 3491

Identification of a MAGE D2 antisense RNA transcript in human tissues.
Periodical: Biochemica et Biophysica Acta Index Medicus:
Authors: Harper R, Xu C, Di P, Chen Y, Privalsky M and Wu R ART
Yr: 2004 Vol: 324 Nbr: 199 - 204 Abs: Pg:

Requirements for two proximal NF-kappa B binding sites and Ikappa B-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway Epithelium.
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Kao CY, Kim C., Huang F, Wu R. ART
Yr: 2008 Vol: 283 (22) Nbr: Abs: Pg: 15309-18

Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma.
Periodical: Journal of Allergy and Clinical Immunology Index Medicus:
Authors: Huang F, Wachi S, Thai P, Loukoianov A, Tan KH, Forteza RM, Wu R ART
Yr: 2008 Vol: 121 (6) Nbr: Abs: Pg: 1415-21