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Steven Dubinett, M.D.

University of California, Los Angeles # of Grants: 5

Grants

Local Cytokine Immunotherapy for Lung Cancer 1992 (Cycle 1) $225,000
Cancer New Investigator Awards

IL-12 genetic immunotherapy for lung cancer 1999 (Cycle 8) $75,000
Cancer Inno Dev & Exp Awards (IDEAS)

Cytokine gene-modified dendritic cells for lung cancer 2000 (Cycle 9) $590,523
Cancer Research Project Awards

COX-2 regulation of vaccination responses in lung cancer 2004 (Cycle 13) $379,362
Cancer Research Project Awards

Biological Impact of E-Cigarettes on Lung Carcinogenesis 2014 (Cycle 23) $445,314
Regulatory Science/New Products Research Project Awards
Publications

Interleukin-2-responsive wound-infiltrating lymphocytes in surgical adjuvant cancer immunotherapy
Periodical: Immunological Investigations Index Medicus:
Authors: Dubinett SM, Patrone L, Huang M, et al ART
Yr: 1993 Vol: 22 Nbr: 1 Abs: Pg: 13-23

Intratumoral interleukin-2 immunotherapy: activation of tumor-infiltrating and splenic lymphocytes in vivo
Periodical: Index Medicus:
Authors: Dubinett SM, Patrone L, Tobias J, Cochran AJ, Wen DR, McBride WH ART
Yr: 1993 Vol: 36 Nbr: 3 Abs: Pg: 156-162

In situ regulation of pulmonary macrophage TNF-alpha mRNA expression by IL2
Periodical: Chest Index Medicus:
Authors: Dubinett SM, Huang M, Dhanani S, et al ART
Yr: 1993 Vol: 103 Nbr: 2 Suppl Abs: Pg: 91S-94S

Cytokine immunotherapy of non-small cell lung cancer
Periodical: Regional Immunology Index Medicus:
Authors: Dubinett SM, Kradin RL ART
Yr: 1993 Vol: Nbr: Abs: Pg:

1kBa gene transfer is cytotoxic to squamous cell lung cancer cells and sensitizes them to TNFa-mediated cell death
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Batra RK, Guttridge DC, Brenner DA, Dubinett SM, Baldwin AS, Boucher RC ART
Yr: 1999 Vol: 21 Nbr: Abs: Pg: 238-245

T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function
Periodical: Journal of Immunology Index Medicus:
Authors: Sharma S, Stolina M, Lin Y, et al ART
Yr: 1999 Vol: 163 Nbr: Abs: Pg: 5020-5028

THC-mediated, IL-10 dependent suppression of anti-tumor immunity in murine lung cancer
Periodical: American Journal of Respiratory and Critical Care Medicine Index Medicus:
Authors: Zhu L, Sharma S, Stolina M, et al ART
Yr: 1999 Vol: 159 Nbr: A404 Abs: Pg:

1KBa gene transfer into lung cancer cells induces cytotoxicity and apoptosis
Periodical: American Journal of Respiratory and Critical Care Medicine Index Medicus:
Authors: Batra RK, Guttridge DC, Brenner DA, Dubinett SM, Boucher RC ART
Yr: 1999 Vol: 159 Nbr: A237 Abs: Pg:

Intratumoral administration of cytokiine gene-modified dentritic cells augments specific antitumor immunity and achieves systemic tumor eradication
Periodical: American Journal of Respiratory and Critical Care Medicine Index Medicus:
Authors: Miller PW, Sharma S, Stolina M, et al ART
Yr: 1999 Vol: 159 Nbr: A238 Abs: Pg:

Mechanisms of IL-10-mediated suppression of antigen presentation in lung cancer
Periodical: Proceedings of the American Association for Cancer Research Index Medicus:
Authors: Sharma S, Stolina M, Lin Y, Zhu L, Miller PW, Dubinett SM ART
Yr: 1999 Vol: 40 Nbr: Abs: Pg: 512

Transfer of IL-10 overproducing lymphocytes reverses the antitumor effects of cyclooxygenase 2 inhibition
Periodical: Proceedings of the American Association for Cancer Research Index Medicus:
Authors: Stolina M, Sharma S, Lin Y, et al ART
Yr: 1999 Vol: 40 Nbr: Abs: Pg: 77

Intratumoral administration of cytokine gene-modified dendritic cells augments antigen prsentation and processing in non-small cell lung cancer
Periodical: Proceedings of the American Association for Cancer Research Index Medicus:
Authors: Miller PW, Sharma S, Stolina M, Zhu L, Dubinett SM ART
Yr: 1999 Vol: 40 Nbr: Abs: Pg: 86

Antisense inhibition of cyclooxygenase-2 blocks invasion and promotes apoptosis in non-small cell lung cancer (NSCLC)
Periodical: Cancer Gene Therapy Index Medicus:
Authors: Dohadwala M, Luo J, Lin Y, Sharma S, Stolina M, Dubinett SM ART
Yr: 1999 Vol: 6 Nbr: Abs: Pg: S3

Increased radioisotope uptake in non-small cell lung cancer following transfection with the sodium/iodide symporter gene
Periodical: Cancer Gene Therapy Index Medicus:
Authors: Huang M, Kogai T, Lin Y, et al ART
Yr: 1999 Vol: 6 Nbr: Abs: Pg: S21

Intratumoral administration of adenoviral interleukin-7 gene-modified dendritic cells augments specific antitumor immunity and tumor eradication
Periodical: Human Gene Therapy Index Medicus:
Authors: Miller PW, Sharma S, Stolina M ART
Yr: 2000 Vol: 11 Nbr: Abs: Pg: 53-65

Specific inhibition of cyclooxygenase 2 restores antitumor by altering the balance of IL-10 and IL-12 synthesis
Periodical: Journal of Immunology Index Medicus:
Authors: Stolina M, Sharma S, Lin Y, et al ART
Yr: 2000 Vol: 164 Nbr: Abs: Pg: 361-370

Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells
Periodical: Journal of Immunology Index Medicus:
Authors: Kiertscher SM, Luo J, Dubinett SM, Roth MD ART
Yr: 2000 Vol: 164 Nbr: Abs: Pg: 1269-1276

SLC/6Ckine mediates T-cell-dependent antitumor responses in vivo
Periodical: Journal of Immunology Index Medicus:
Authors: Sharma S, Stolina M, Luo J, et al ART
Yr: 2000 Vol: 164 Nbr: Abs: Pg: 4558-4563

Tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway
Periodical: Journal of Immunology Index Medicus:
Authors: Zhu L, Sharma S, Stolina M, et al ART
Yr: 2000 Vol: Nbr: Abs: Pg:

New gene and cell-base therapies for lung cancer
Periodical: Seminars in Respiratory and Critical Care Medicine Index Medicus:
Authors: Batra RK, Sharma S, Dubinett SM ART
Yr: 2000 Vol: Nbr: Abs: Pg:

Tumor antigens in thoracic malignancies
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Dubinett SM, Batra RK, Miller PW, Sharma S ART
Yr: 2000 Vol: Nbr: Abs: Pg:

Cyclooxygenase-2-dependent invasion and apoptosis resistance in non-small cell lung cancer (NSCLC)
Periodical: American Journal of Respiratory and Critical Care Medicine Index Medicus:
Authors: ART
Yr: 2000 Vol: 161 Nbr: 3 Abs: Pg: A677

Role of GM-CSF and IL-4 in the development of dendritic cell (DC) subsets and their localization in spleen of mice
Periodical: American Association for Cancer Research Index Medicus:
Authors: Basak SM, Trejo DT, Stolina M, Dubinett SM, Roth MD ART
Yr: 2000 Vol: 41 Nbr: Abs: Pg: 2

Lung cancer cyclooxygenase-2 dependent inhibition of dendritic cells maturation and function
Periodical: Proceedings of the American Association for Cancer Research Index Medicus:
Authors: Stolina M, Sharma S, Zhu L, Dubinett SM ART
Yr: 2000 Vol: 41 Nbr: Abs: Pg: 619

Intratumoral dendritic cell based genetic immunotherapy for lung cancer
Periodical: Methods in Molecular Genetics Index Medicus:
Authors: Sharma S, Yang K, Dubinett SM ART
Yr: 0 Vol: Nbr: Abs: Pg:

Secondary lymphoid chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalvelolar cell carcinoma.
Periodical: Cancer Research Index Medicus:
Authors: Sharma S, Stolina M, Zhu L, Lin Y, Batra R, Huang M, Strieter R, and Dubinett SM ART
Yr: 2001 Vol: 61 Nbr: Abs: Pg: 6406-6412

Interleukin-7 inhibits both TGF-beta production and signaling in pulmonary fibrosis fibroblsts.
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Huang M, Sharma S, Zhu SX, Luo J, Keane MP, Burdick MD, Lin YQ et al ART
Yr: 2002 Vol: 109 Nbr: Abs: Pg: 931-937

Non-small cell lung cancer-derived soluble mediators enhance apoptosis in T lymphocytes through an I kappa B kinase-dependent mechanism
Periodical: Cancer Research Index Medicus:
Authors: Batra R, Lin Y, Gardner B, Luo J, Dohadwala M, Sharma S, Dubinett S ART
Yr: 2003 Vol: 63 Nbr: Abs: Pg: 642-646

Abnormal IL-10Ralpha expression contributes to the maintenance of elevated COX-2 in non-small cell lung cancer cells.
Periodical: Cancer Research Index Medicus:
Authors: Heuze-Vourc'h N, Zhu L, Krysan K, Batra RK, Sharma S, Dubinett S ART
Yr: 2003 Vol: 63 Nbr: Abs: Pg: 766-770

Tumor COX-2-dependent regulation of murine dendritic cell function.
Periodical: Clinical Cancer Research Index Medicus:
Authors: Sharma S, Stolina M, Baratelli F, Lin JF, Zhu L, Lin Y, Batra RK, Dubinett S, et al. ART
Yr: 2003 Vol: 9 Nbr: Abs: Pg: 961-968

IL-10 mediates the sigma receptor-dependent suppression of antitumor immunity.
Periodical: Journal of Immunology Index Medicus:
Authors: Zhu LX, Sharma S, Gardner B, Escuadro B, Atianzar K, Tashkin D, Dubinett S ART
Yr: 2003 Vol: 170 Nbr: Abs: Pg: 3585-3591

The secondary lymphoid tissue chemokine (SLC)-mediated antitumor response requi4res the in vivo induction of interferon inducible protein-10 (IP-10) and monokine induced by interferon gamma (MIG).
Periodical: Molecular Cancer Research Index Medicus:
Authors: Sharma S, Yang C, Zhu LX, Batra RK, Strieter RM, Dubinett S ART
Yr: 2003 Vol: 2 Nbr: Abs: Pg: 22

Non-radioactive iodide effectively induces apoptosis in genetically modified lung cancer cells.
Periodical: Cancer Research Index Medicus:
Authors: Zhang I, Sharma S, Zhu LX, Kogai T, Hershman JM, Brent GA, Dubinett SM, Huang M ART
Yr: 2003 Vol: 63 Nbr: Abs: Pg: 5065-5072

Methanandamide increases COX-2 expression and tumor growth in murine lung cancer.
Periodical: FASEB Journal Index Medicus:
Authors: Gardner B, Zhui L, Sharma S, Tashkin DP, Dubinett SM ART
Yr: 2003 Vol: 17 Nbr: 14 Abs: Pg: 2157-2159

IL-7 gene modified dentritic cells reduce pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.
Periodical: Human Gene Therapy Index Medicus:
Authors: Sharma S, Batra RK, Yang SC, Hillinger S, Zhu L, Atianzar K, Dubinett SM, et al. ART
Yr: 2003 Vol: 14 Nbr: Abs: Pg: 1511-1524

Overexpression of CCL-21/secondary lymphoid tissue chemokine in human dendritic cells augments chemotactic activities for lymphocytes and antigen presenting cells.
Periodical: Molecular Cancer Research Index Medicus:
Authors: Riedl K, Baratelli F, Batra R, Yang SC, Luo J, Escuadro B, Figlin R, Dubinett SM ART
Yr: 2003 Vol: 2 Nbr: Abs: Pg: 35

COX-2-dependent stabilization of survivin in non-small cell lung cancer.
Periodical: FASEB Journal Index Medicus:
Authors: Krysan K, Merchant FH, Zhu L, Dohadwala M. Luo J, et al. ART
Yr: 2004 Vol: 18 Nbr: 1 Abs: Pg: 206-208

Epstein barr virus-induced molecule I ligand chemokine (ELC/CCL19) promotes IFNy-dependent antitumor responses in a lung cancer model.
Periodical: Journal of Immunology Index Medicus:
Authors: Hillinger S, Yang SC, Zhu L, Huang M, Duckett R, Dubinett SM, et al. ART
Yr: 2003 Vol: 171 Nbr: Abs: Pg: 6456-6457

Celecoxib modulates the capacity for PGE2 and IL-10 production in alveolar macrophages.
Periodical: Clinical Cancer Research Index Medicus:
Authors: Mao JT, Roth MD, Serio KJ, Baratelli F, Zhu L, Holmes EC, Strieter RM, Dubinett SM ART
Yr: 2003 Vol: 9 Nbr: 5835-5841 Abs: Pg:

Cyclooxygenase-2 in lung cancer.
Periodical: Prog Exp Tumor Research Index Medicus:
Authors: Dubinett SM, Sharma S, Huang M, Pold M. Mao JT ART
Yr: 2003 Vol: 37 Nbr: Abs: Pg: 138-162

Cyclooxygenase-2 dependent expression of angiogenic CXC chemokines, ENA-78/CXCL5 and IL-8/CXCL8, in human non-small cell lung cancer.
Periodical: Cancer Research Index Medicus:
Authors: Pold M, Zhu L, Sharma S, Burdick M, Dubinett SM, et al. ART
Yr: 2004 Vol: 64 Nbr: Abs: Pg: 1853-1860

Intratumoral administration of dendritic cells overexpressing CCL21 generates systemic antitumor responses and confers tumor immunity.
Periodical: Clinical Cancer Research Index Medicus:
Authors: Yang SC, Hillinger S, Riedl K, Zhang L, Zhu L, Huang M, Dubinett SM, et al. ART
Yr: 2004 Vol: 10 Nbr: Abs: Pg: 2891-2901

Cyclooxygenase-2-dependent expression of survivin in non-small cell lng cancer.
Periodical: Chest Index Medicus:
Authors: Krysan K. Dohadwala M, Luo J, Lin Y, Zhu L, Heuze-Vourc'h N, Dubinett SM, et al. ART
Yr: 2004 Vol: 125 Nbr: 5 Suppl Abs: Pg: 140S

IL-7 and TGF-Beta play counter-regulatory roles in PKC-8-dependent control of fibroblast collagen synthesis in pulmonary fibrosis.
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Zhang L, Keane MP, Zhu LX, Sharma S, Rozengurt E. Strieter RM, Dubinett SM, et al. ART
Yr: 2004 Vol: 279 Nbr: 27 Abs: Pg: 28315-28319

Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small cell lung cancer.
Periodical: Cancer Research Index Medicus:
Authors: Pold M, Krysan K, Pold A, Dohadwala M, Dubinett SM, et al. ART
Yr: 2004 Vol: 64 Nbr: Abs: Pg: 6549-6555

Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer.
Periodical: Cancer Research Index Medicus:
Authors: Krysan K, Dalwadi II, Sharma S, Pold M, Dubinett SM ART
Yr: 2004 Vol: 64 Nbr: Abs: Pg: 6359-6362

Prostaglandin E2-dependent enhancement of tissue inhibitors of metalloproteinases-I production limits dendritic cell migration through extracellular matrix.
Periodical: Journal of Immunology Index Medicus:
Authors: Baratelli F, Heuze-Vourc'h N, Drysan K, Dubinett SM, et al. ART
Yr: 2004 Vol: 173 Nbr: Abs: Pg: 5458-5466

Modulation of pulmonary leukotriene B4 production by cyclooygenase-2 inhibitors and lipopolysaccharide.
Periodical: Clinical Cancer Research Index Medicus:
Authors: Mao JT, Tsu IH, Dubinett SM, et al. ART
Yr: 2004 Vol: 10 Nbr: Abs: Pg: 6872-6878

COX-2-dependent stabilization of survivin in non-small cell lung cancer.
Periodical: FASEB Journal Index Medicus:
Authors: Dubinett SM, Krysan K, Merchant FH, Zhu L, Dohadwala M. Luo J, Lin Y, et al. ART
Yr: 2004 Vol: 18 Nbr: 1 Abs: Pg: 206 - 208

Cyclooxygenase-2 dependent expression of angiogenic CXC chemokines, ENA-78/CXCL5 and IL-8/CXCL8, in human non-small cell lung cancer.
Periodical: Cancer Research Index Medicus:
Authors: Dubinett SM, Pold M, Zhu L, Sharma S, Burdick M, Ying L, Lee PN, Pold A, et al. ART
Yr: 2004 Vol: 64 Nbr: Abs: Pg: 1853 - 1860

Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small cell lung cancer.
Periodical: Cancer Research Index Medicus:
Authors: Dubinett SM, Pold M, Krysan K, Pold A, Dohadwala M. Heuze-Vourc'h Mao JT, et al. ART
Yr: 2004 Vol: 64 Nbr: Abs: Pg: 6549 - 6555

Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer.
Periodical: Cancer Research Index Medicus:
Authors: Krysan K, Dalwadi H, Sharma S, Pold M, Dubinett SM ART
Yr: 2004 Vol: 64 Nbr: Abs: Pg: 6359 - 6362

Prostaglandin E2-Dependent enhancement of tissue inhibitors of metalloproteinases-1 production limits dendritic cell migration through extracellular matrix.
Periodical: Journal of Immunology Index Medicus:
Authors: Dubinett SM, Baratelli F, Heuze-Vourc'h N, Krysan K, Dohadwala M, Riedl K, Sharma S ART
Yr: 2004 Vol: 173 Nbr: Abs: Pg: 5458 - 5466

Modulation of pulmonary leukotriene B4 production by cyclooygenase-2 inhibitors and lipopolysaccharide.
Periodical: Clinical Cancer Research Index Medicus:
Authors: Mao JT, Tsu IH, Dubinett SM, Adams B, Sarafian T, Baratelli F, Roth MD, Serio KJ ART
Yr: 2004 Vol: 10 Nbr: Abs: Pg: 6872 - 6878

Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+CD25+T regulatory cell activities in lung cancer.
Periodical: Cancer Research Index Medicus:
Authors: Dubinett SM, Sharma S, Yang SC, Zhu L, Reckamp K, Gardner B, Baratelli F, et al. ART
Yr: 2005 Vol: 65 Nbr: 12 Abs: Pg: 5211 - 5220

PGE2 confers survivin-dependent apoptosis resistance in human monocyte-derived dendritic cells.
Periodical: Journal of Leukocyte Biology Index Medicus:
Authors: Dubinett SM, Baratelli F, Krysan K, Heuze-Vourc'h N, Zhu L. Escuadro B, Sharma S, et al. ART
Yr: 2005 Vol: Nbr: Abs: Pg:

IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression.
Periodical: Biochem Biophys Res Commun Index Medicus:
Authors: Dubinett SM, Heuze-Vourc'h N, Liu M, Dalwadi H, Baratelli FE, Zhu L, Goodglick L, et al. ART
Yr: 2005 Vol: 333 Nbr: 2 Abs: Pg: 470 - 475

COX-2 inhibition, promotes IFNy-dependent enhancement of anti-tumor immunity.
Periodical: Journal of Immunology Index Medicus:
Authors: Dubinett SM, Sharma S, Zhu L, Hillinger S, Yang SC, Atianzar K, Gardner B, et al. ART
Yr: 2005 Vol: 175 Nbr: 2 Abs: Pg: 813 - 819

PGE2 activates MAPK/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an EGF receptor-independent manner.
Periodical: Cancer Research Index Medicus:
Authors: Dubinett SM, Krysan K, Reckamp K, Dalwadi H, Sharma S Rozengurt E, Dohadwala M ART
Yr: 2005 Vol: 65 Nbr: 14 Abs: Pg: 6275 - 6281

PGE2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells.
Periodical: Journal of Immunology Index Medicus:
Authors: Dubinett SM, Baratelli F, Lin Y, Zhu L, Yang SC, Hueze-Vourc'h N,Zeng G, et al. ART
Yr: 2005 Vol: 175 Nbr: Abs: Pg: 1483 - 1490

Arginase I in myeloid suppressor cells is induced by cox-2 in lung carcinoma
Periodical: Journal of Experimental Medicine Index Medicus:
Authors: Rodriquez PC, Hernandez PC, Quiceno D, Dubinett SM, Zabaleta J, Ochoa JB Gilbert J OChoa A ART
Yr: 2005 Vol: 202 Nbr: 7 Abs: Pg: 931-9

Cycloooxygenase 2 dependent regulation of STAT3 pathways in NSCLC
Periodical: Clinical Cancer Research Index Medicus:
Authors: Dalwadi H, Krysan K, Heuze-Vourch N, Sharma S, Dohadwala M, Riedi K, Cacalano N, Dubinett ART
Yr: 2005 Vol: 11 Nbr: 21 Abs: Pg: 7674-82

IL-4 regulates COX-2 and PGE2 production in Human non-small cell lung cancer
Periodical: Biochem Biophys Res Commun Index Medicus:
Authors: Cui X, Yang SC, Sharma S, Heuze Vourch N, Dubinett SM ART
Yr: 2006 Vol: 343 Nbr: 4 Abs: Pg: 995-1001

Cyclooxygenase 2 dependent regulation of E-Cadherin prostaglandin E2 induces transcriptional repressors ZEB1 and snail in non small cell lung cancer
Periodical: Cancer Research Index Medicus:
Authors: Dohadwala M, Yang SC , Luo J, Sharma S, Batra RK, Huang M, Lin Y Good Glick L, Krysan K, F ART
Yr: 2006 Vol: 66 Nbr: 10 Abs: Pg: 5338-45