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David Comings, M.D.

Beckman Research Institute of the City of Hope # of Grants: 3

Grants

The Dopamine D2 Receptor in Nicotine Addiction 1995 (Cycle 4) $304,790
General Biomedical Science Research Project Awards

The role of multiple genes in susceptibility to smoking 1997 (Cycle 6) $557,829
Epidemiology Research Project Awards

The Dopamine D2 Receptor in Nicotine Addiction 1994 (Cycle 3) $162,870
Nicotine Dependence Research Project Awards
Publications

Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviors
Periodical: Pharmacogenetics Index Medicus:
Authors: Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJH, Comings DE ART
Yr: 1995 Vol: 5 Nbr: 3 Abs: Pg: 121-141

The Dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking
Periodical: Pharmacogenetics Index Medicus:
Authors: Comings DE, Ferry L, Bradshaw-Robinson S, et al ART
Yr: 1996 Vol: 6 Nbr: 1 Abs: Pg: 73-79

Reward deficiency syndrome
Periodical: American Scientist Index Medicus:
Authors: Blum K, Cull JG, Braverman ER, Commings DE ART
Yr: 1996 Vol: 84 Nbr: 2 Abs: Pg: 132-145

Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat
Periodical: Genomics Index Medicus:
Authors: Comings DE, Muhleman D, Dieta G, Sherman M, Forest GL ART
Yr: 1995 Vol: 29 Nbr: 2 Abs: Pg: 390-396

Tourette syndrome: a hereditary neuropsyhciatric spectrum disorder
Periodical: Annals of Clinical Psychiatry Index Medicus:
Authors: Comings DE ART
Yr: 1994 Vol: 6 Nbr: 4 Abs: Pg: 235-245

A study of the dopamine D2 receptor gene in pathological gambling
Periodical: Pharmacogenetics Index Medicus:
Authors: Comings DE, Rosenthal RJ, Lesieur HR, et al ART
Yr: 1996 Vol: 6 Nbr: Abs: Pg: 223-234

Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder
Periodical: American Journal of Medical Genetics Index Medicus:
Authors: Comings DE, Wu S, Chiu C, et al ART
Yr: 1996 Vol: 67 Nbr: 3 Abs: Pg: 264-288

Exon and intron variants in the human trypophan 2,2-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders
Periodical: Pharmacogenetics Index Medicus:
Authors: Comings DE ART
Yr: 1996 Vol: Nbr: 6 Abs: Pg:

The molecular genetics of pathological gambing
Periodical: CNS Spectrums Index Medicus:
Authors: Coming, DE ART
Yr: 1998 Vol: Nbr: Abs: Pg:

Exon & intron variants in the human tryptophan 2.3-dioxygenase gene: potential association with Tourette Syndrome, substance abuse & other disorders
Periodical: Pharmacogenetics Index Medicus:
Authors: Comings DE, et al ART
Yr: 1996 Vol: Nbr: Abs: Pg: 6,307-6318

Correlation of length of VNTR alleles at the X-linked MAOA gene & phenotypic effect in Tourette Syndrome & drug abuse
Periodical: Molecular Psychiatry Index Medicus:
Authors: Gade R, Muhleman D, Blake H, MacMurray J, et al ART
Yr: 1997 Vol: Nbr: Abs: Pg:

Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE, et al ART
Yr: 1997 Vol: 2 Nbr: Abs: Pg: 44-56

Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric disorders, & interaction with the dopamine D2 receptor (DRD2) gene
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE, et al ART
Yr: 1996 Vol: 1 Nbr: Abs: Pg: 325-335

Polygenic inheritance and micro/minisatellites
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE ART
Yr: 0 Vol: Nbr: Abs: Pg:

Cannabinoid receptor gene (CNRI): association with IV drug use
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE, Muhleman D, Gade R, et al ART
Yr: 1997 Vol: 2 Nbr: Abs: Pg: 161-168

Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB)
Periodical: Molecular Psychiatry Index Medicus:
Authors: Blum K, Braverman ER, Comings DE ART
Yr: 1997 Vol: 2 Nbr: Abs: Pg: 239-246

Polygenic inheritance and micro/minisatellites
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE ART
Yr: 1998 Vol: 3 Nbr: Abs: Pg: 21-31

Why different rules are required for polygenic inheritance: lessons from studies of the DRD2 gene
Periodical: Alcohol Index Medicus:
Authors: Comings DE ART
Yr: 1998 Vol: 16 Nbr: Abs: Pg: 61-70

Correlation of length of VNTR alleles of the X-linked MAOA gene and phenotypic effect in Tourette syndrome and drug abuse
Periodical: Molecular Psychiatry Index Medicus:
Authors: Gade R, Muhleman D, Blake H, et al ART
Yr: 1998 Vol: 3 Nbr: Abs: Pg: 50-60

Association of catechol-O-methyltransferase (COMT) gene with frontal lobe function, memory and creativity
Periodical: American Journal of Medical Genetics Index Medicus:
Authors: Harrelson J, Muhleman D, Date-Andavolu R, et al ART
Yr: 1998 Vol: Nbr: Abs: Pg:

Androgen receptor gene, conduct disorder and oppositional defiant disorder
Periodical: American Journal of Medical Genetics Index Medicus:
Authors: Comings DE, Wu S, Muhleman D ART
Yr: 1998 Vol: 81 Nbr: Abs: Pg: 549-550

Association of DRD5 dinucleotide repeat polymorphism with substance abuse, depression and adult ADD
Periodical: American Journal of Medical Genetics Index Medicus:
Authors: Comings DE, MacMurray J, Dade-Andavolu R, et al ART
Yr: 1998 Vol: Nbr: Abs: Pg:

Association of endopeptidase (CD10NE) dinucleotide repeat polymorphism with anxiety, depression, and P300 amplitude
Periodical: American Journal of Medical Genetics Index Medicus:
Authors: Johnson JP, Dietz G, Gade-Andavolu R, et al ART
Yr: 1998 Vol: 81 Nbr: Abs: Pg: 524

Gene-environment interactions in the behavioral expression of the melanocortin-3 (MC3R) gene
Periodical: American Journal of Medical Genetics Index Medicus:
Authors: Gade-Andavolu R, MacMurray J, Muhleman D, et al ART
Yr: 1998 Vol: Nbr: Abs: Pg:

Norepinephrine genes, ADHD and learning disorders
Periodical: American Journal of Medical Genetics Index Medicus:
Authors: Comings DE, Gade-Andavolu R, Gonzalez N, et al ART
Yr: 1998 Vol: Nbr: Abs: Pg:

The DRD4 gene and spiritual transcendence scale of character temperament index
Periodical: Psychiatric Genetics Index Medicus:
Authors: Comings DE, Gonzales N, Saucier G, Johnson JP, MacMurray JP ART
Yr: 2001 Vol: Nbr: Abs: Pg:

Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes
Periodical: Clinical Genetics Index Medicus:
Authors: Comings DE, Gade-Andavolu R, Gonzalez N, et al ART
Yr: 2000 Vol: 57 Nbr: Abs: Pg: 178-196

Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder
Periodical: Clinical Genetics Index Medicus:
Authors: Comings DE, Gade-Andavolu R, Gonzalez N, et al ART
Yr: 2000 Vol: 58 Nbr: Abs: Pg: 31-40

Multivariate analysis of 59 candidate genes in personality traits: the temperament character inventory
Periodical: Clinical Genetics Index Medicus:
Authors: Comings DE, Gade-Andavolu R, Gonzalez N, et al ART
Yr: 2000 Vol: 58 Nbr: Abs: Pg: 375-385

Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE, et al ART
Yr: 1997 Vol: 2 Nbr: Abs: Pg: 44-56

Association between the cannabinoid receptor gene (CNR1), and the P300 wave of event-related potentials, and drug dependence
Periodical: Molecular Psychiatry Index Medicus:
Authors: Johnson JP, et al ART
Yr: 1997 Vol: 2 Nbr: Abs: Pg: 169-171

A simple restriction endonuclease based test for the dopamine D2 receptor gene (DRD2) haplotypes: linkage disequilibrium of of the haplotypes with the Taq A1 allele
Periodical: Psychiatric Genetics Index Medicus:
Authors: Dietz G, Comings DE ART
Yr: 1997 Vol: 7 Nbr: Abs: Pg: 133-135

The molecular genetics of pathological gambling
Periodical: CNS Spectrums Index Medicus:
Authors: Comings DE ART
Yr: 1998 Vol: 3 Nbr: Abs: Pg: 20-37

G5644A polymorphism in the interferon-gamma (INFG) gene
Periodical: Psychiatric Genetics Index Medicus:
Authors: Wu S, Comings DE ART
Yr: 1998 Vol: 8 Nbr: Abs: Pg: 57

Potential role of the estrogen receptor gene (ESR1) in anxiety
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE, Muhleman D, Johnson P, MacMurray JP ART
Yr: 1999 Vol: 4 Nbr: Abs: Pg: 374-377

Clinical implications of dopamine D2 receptor gene susceptibility of posttraumatic stress disorder
Periodical: Essential Pharmacology Index Medicus:
Authors: Comings DE ART
Yr: 1999 Vol: 1 Nbr: Abs: Pg: 93-104

Studies of the 48 bp repeat of the DRD4 gene in impulsive-addictive behaviors: tourette syndrome, ADHD, pathological gambling and substance abuse
Periodical: American Journal of Medical Genetics Index Medicus:
Authors: Coming DE, et al ART
Yr: 1999 Vol: 88 Nbr: Abs: Pg: 358-368

Association of the dopamine DRD3 receptor gene with cocaine dependence
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE, et al ART
Yr: 1999 Vol: 4 Nbr: Abs: Pg: 484-487

The proenkephalin gene (PENK) and opioid dependence
Periodical: NeuroReport Index Medicus:
Authors: Comings DE, et al ART
Yr: 1999 Vol: 10 Nbr: Abs: Pg: 1133-1135

Addictive effect of three noradrenergic genes (ADRA2A, ADRA2C, DBH) on attention deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects
Periodical: Clinical Genetics Index Medicus:
Authors: Comings DE, et al ART
Yr: 1999 Vol: 55 Nbr: Abs: Pg: 160-172

SNPs and polygenic disorders: a less gloomy view
Periodical: Molecular Psychiatry Index Medicus:
Authors: Comings DE ART
Yr: 1999 Vol: 4 Nbr: Abs: Pg: 314-316

A common C-1018G polymorphism in the human 5-HTR1A receptor gene
Periodical: Psychiatric Genetics Index Medicus:
Authors: Wu S, Comings DE ART
Yr: 1999 Vol: 9 Nbr: Abs: Pg: 105-106

Association of the enkephalinase gene with low amplitude P300 waves
Periodical: NeuroReport Index Medicus:
Authors: Comings DE, Dietz G, Johnson JPMJP ART
Yr: 1999 Vol: 10 Nbr: Abs: Pg: 2283-2285

Association of the androgen receptor gene (AR) with ADHD and conduct disorder
Periodical: NeuroReport Index Medicus:
Authors: Comings DE, Chen C, Wu S, Muhleman D ART
Yr: 1999 Vol: 10 Nbr: Abs: Pg: 1589-1592

Two single polymorphisms in the promoter region of the human phenylethanolamine N-methyltransferase PNMT gene
Periodical: Psychiatric Genetics Index Medicus:
Authors: Wu S, Comings DE ART
Yr: 2000 Vol: 9 Nbr: Abs: Pg: 187-188

Association between the adrenergic alpha2A, receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects
Periodical: Psychiatric Genetics Index Medicus:
Authors: Comings DE, et al ART
Yr: 2000 Vol: 10 Nbr: Abs: Pg: 160-172

The additive effect of neurotransmitter genes in pathological gambling: the interaction of 31 candidate genes
Periodical: Clinical Genetics Index Medicus:
Authors: Comings DE, Gade-Andavolu R, Gonzalez N, et al ART
Yr: 0 Vol: Nbr: Abs: Pg:

Cholecystokinin (CCK) gene as a risk factor for smoking: studies in two independent samples
Periodical: Index Medicus:
Authors: Comings DE, Wu S, Gonzalez N, McGue M, Peters WW, MacMurray JP ART
Yr: Vol: Nbr: Abs: Pg: