Arieh Warshel, Ph.D. 
		
		 
       
          | 
          University of Southern California  
           | 
           | 
          
           # of Grants: 1 | 
        
        
      
      
      
       Grants
      
      
      
      
     
      Publications 
     
            
      
        
          | Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins | 
        
        
        
          | Periodical: Nature Structural Biology | 
          Index Medicus:  | 
        
        
          | Authors: Schweins T, Geyer M, Scheffzek K, et al |  
          ART | 
        
        
          | Yr: 1995 | 
          Vol: 2 | 
          Nbr: 1 | 
          Abs:  | 
          Pg: 36-44 | 
        
      
            
      
        
          | Electrostatic control of GTP and GDP binding in the oncoprotein p21 ras | 
        
        
        
          | Periodical: Structure | 
          Index Medicus:  | 
        
        
          | Authors: Muegge I, Schweins T, Langen R, Warshel A |  
          ART | 
        
        
          | Yr: 1996 | 
          Vol: 4 | 
          Nbr:  | 
          Abs:  | 
          Pg: 475-489 | 
        
      
            
      
        
          | Mechanistic analysis of the observed linear free energy relationships in p21ras and related system | 
        
        
        
          | Periodical: Biochemistry | 
          Index Medicus:  | 
        
        
          | Authors: Schweins T, Warshel A |  
          ART | 
        
        
          | Yr: 1996 | 
          Vol: 35 | 
          Nbr:  | 
          Abs:  | 
          Pg: 14232 | 
        
      
            
      
        
          | Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras | 
        
        
        
          | Periodical: Biochemistry | 
          Index Medicus:  | 
        
        
          | Authors: Schweins T, Geyer M, Kalbitzer HR, et al |  
          ART | 
        
        
          | Yr: 1996 | 
          Vol: 35 | 
          Nbr:  | 
          Abs:  | 
          Pg: 14225 | 
        
      
            
      
        
          | A fundamental assumption about OH- attack in phosphate hydrolysis is not fully justified | 
        
        
        
          | Periodical: Journal of the American Chemistry Society | 
          Index Medicus:  | 
        
        
          | Authors: Florian J, Warshel A |  
          ART | 
        
        
          | Yr: 1997 | 
          Vol: 119 | 
          Nbr:  | 
          Abs:  | 
          Pg: 5473 | 
        
      
            
      
        
          | The role of the metal ion in the p21 ras catalyzedGTP-hydrolysis: Mn2+ versus Mg2+ | 
        
        
        
          | Periodical: Journal of Molecular Biology | 
          Index Medicus:  | 
        
        
          | Authors: Schweins T, Scheffzek K, Assheuer R, Wittinghofer A |  
          ART | 
        
        
          | Yr: 1997 | 
          Vol: 266 | 
          Nbr:  | 
          Abs:  | 
          Pg: 847 | 
        
      
            
      
        
          | Electrostatic contributions to protein-protein binding affinities: application to Rap/Raf interaction | 
        
        
        
          | Periodical: Proteins : Structure, Function, and Genetics | 
          Index Medicus:  | 
        
        
          | Authors: Muegge I, Schweins T, Warshel A |  
          ART | 
        
        
          | Yr: 1998 | 
          Vol: 30 | 
          Nbr:  | 
          Abs:  | 
          Pg: 407 | 
        
      
            
      
        
          | Phosphate ester hydrolysis in aqueous solution: associative versus dissociative mechanisms | 
        
        
        
          | Periodical: Journal of Chemical Physics | 
          Index Medicus:  | 
        
        
          | Authors: Florian J, Warshel A |  
          ART | 
        
        
          | Yr: 1998 | 
          Vol: 102 | 
          Nbr:  | 
          Abs:  | 
          Pg: 719-734 | 
        
      
            
      
        
          | Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins | 
        
        
        
          | Periodical: Nature Structural Biology | 
          Index Medicus:  | 
        
        
          | Authors: Schweins T, Geyer M, Scheffzek K, et al |  
          ART | 
        
        
          | Yr: 1995 | 
          Vol: 2 | 
          Nbr: 1 | 
          Abs:  | 
          Pg: 36-44 | 
        
      
            
      
        
          | Electrostatic control of GTP and GDP binding in the oncoprotein p21 ras | 
        
        
        
          | Periodical: Structure | 
          Index Medicus:  | 
        
        
          | Authors: Muegge I, Schweins T, Langen R, Warshel A |  
          ART | 
        
        
          | Yr: 1996 | 
          Vol: 4 | 
          Nbr:  | 
          Abs:  | 
          Pg: 475-489 | 
        
      
            
      
        
          | Mechanistic analysis of the observed linear free energy relationships in p21ras and related system | 
        
        
        
          | Periodical: Biochemistry | 
          Index Medicus:  | 
        
        
          | Authors: Schweins T, Warshel A |  
          ART | 
        
        
          | Yr: 1996 | 
          Vol: 35 | 
          Nbr:  | 
          Abs:  | 
          Pg: 14232 | 
        
      
            
      
        
          | Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras | 
        
        
        
          | Periodical: Biochemistry | 
          Index Medicus:  | 
        
        
          | Authors: Schweins T, Geyer M, Kalbitzer HR, et al |  
          ART | 
        
        
          | Yr: 1996 | 
          Vol: 35 | 
          Nbr:  | 
          Abs:  | 
          Pg: 14225 | 
        
      
            
      
        
          | A fundamental assumption about OH- attack in phosphate hydrolysis is not fully justified | 
        
        
        
          | Periodical: Journal of the American Chemistry Society | 
          Index Medicus:  | 
        
        
          | Authors: Florian J, Warshel A |  
          ART | 
        
        
          | Yr: 1997 | 
          Vol: 119 | 
          Nbr:  | 
          Abs:  | 
          Pg: 5473 | 
        
      
            
      
        
          | The role of the metal ion in the p21 ras catalyzedGTP-hydrolysis: Mn2+ versus Mg2+ | 
        
        
        
          | Periodical: Journal of Molecular Biology | 
          Index Medicus:  | 
        
        
          | Authors: Schweins T, Scheffzek K, Assheuer R, Wittinghofer A |  
          ART | 
        
        
          | Yr: 1997 | 
          Vol: 266 | 
          Nbr:  | 
          Abs:  | 
          Pg: 847 | 
        
      
            
      
        
          | Electrostatic contributions to protein-protein binding affinities: application to Rap/Raf interaction | 
        
        
        
          | Periodical: Proteins : Structure, Function, and Genetics | 
          Index Medicus:  | 
        
        
          | Authors: Muegge I, Schweins T, Warshel A |  
          ART | 
        
        
          | Yr: 1998 | 
          Vol: 30 | 
          Nbr:  | 
          Abs:  | 
          Pg: 407 | 
        
      
            
      
        
          | Phosphate ester hydrolysis in aqueous solution: associative versus dissociative mechanisms | 
        
        
        
          | Periodical: Journal of Chemical Physics | 
          Index Medicus:  | 
        
        
          | Authors: Florian J, Warshel A |  
          ART | 
        
        
          | Yr: 1998 | 
          Vol: 102 | 
          Nbr:  | 
          Abs:  | 
          Pg: 719-734 |