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Xiao-Kun Zhang, Ph.D.

The Burnham Institute for Medical Research # of Grants: 4

Grants

Does nicotine inhibit anticancer activities of Vitamin A? 1997 (Cycle 6) $788,808
Cancer Research Project Awards

Molecular Mechanism of Retinoic Acid Action 1992 (Cycle 1) $75,600
General Biomedical Science Postdoctoral Fellowship Awards

Novel agents for apoptosis of lung cancer 2002 (Cycle 11) $787,977
Cancer Research Project Awards

Vitamin A derivatives as antagonists of nicotine effects 2004 (Cycle 13) $670,085
Cancer Research Project Awards
Publications

Ligand-binding domain of thyroid hormone receptors modulates DNA binding and determines their bifunctional roles
Periodical: New Biologist Index Medicus:
Authors: Zhang XK, Wills KN, Graupner Gerhart, et al. ART
Yr: 1991 Vol: 3 Nbr: 2 Abs: Pg: 169-181

Thyroid hormone receptors repress estrogen receptor activation of a TRE
Periodical: Molecular Endocrinology Index Medicus:
Authors: Graupner G, Zhang X, Tzukerman M, et al ART
Yr: 1992 Vol: 5 Nbr: 3 Abs: Pg: 365-372

Regulatory functions of a non-ligand-binding thyorid hormone receptor isoform
Periodical: Index Medicus:
Authors: Hermann T, Zhang X, Tzukerman M, et al ART
Yr: 1992 Vol: 2 Nbr: 7 Abs: Pg: 565-574

Coordinate expression of functionally distinct thyroid hormone receptor alpha isoforms during neonatal brain development
Periodical: Molecular Endocrinology Index Medicus:
Authors: Wills KN, Zhang XK, Pfahl M ART
Yr: 1991 Vol: 5 Nbr: 8 Abs: Pg: 1109-1119

Inhibition of estrogen receptor activity by the tumor promoter 12-O-Tetradeconylphorbol-13-Acetate: a molecular analysis
Periodical: Molecular Endocrinology Index Medicus:
Authors: Tzukerman M, Zhang XK, Pfahl M ART
Yr: 1991 Vol: 5 Nbr: 12 Abs: Pg: 1983-1992

Antagonsism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation
Periodical: New Biologist Index Medicus:
Authors: Yang-Yen HF, Zhang XK, Graupner G, et al ART
Yr: 1991 Vol: 3 Nbr: 12 Abs: Pg: 1206-1219

DNA binding and dimerization determinants for thyroid hormone receptor alpha and its interaction with a nuclear protein
Periodical: Molecular Endocrinology Index Medicus:
Authors: Zhang XK, Tran PB, Pfahl M ART
Yr: 1991 Vol: 5 Nbr: 12 Abs: Pg: 1909-1920

Novel pathway for thyroid hormone receptor action through interaction with jun and fos oncogene activities
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Zhang XK, Wills KN, Husmann M, Hermann T, Pfahl M ART
Yr: 1991 Vol: 11 Nbr: 12 Abs: Pg: 6016-6025

Retinoid X receptor is an auxiliary protein for thyorid hormone and retinoic acid receptor
Periodical: Nature Index Medicus:
Authors: Zhang XK, Hoffmann B, Tran PB, Graupner G, Pfahl M ART
Yr: 1992 Vol: 355 Nbr: 6359 Abs: Pg: 441-446

RARgamma2 expression is regulated through a retinoic acid response element embedded in SP1 sites
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Lehmann JM, Zhang XK, Pfahl M ART
Yr: 1992 Vol: 12 Nbr: Abs: Pg: 2976-2985

Heterodimeric receptor complexes determine T3 and retinoid signaling specificities
Periodical: Molecular Endocrinology Index Medicus:
Authors: Hermann T, Hoffmann B, Zhang XK, Tran P, Pfahl M ART
Yr: 1992 Vol: Nbr: Abs: Pg:

9-cis retinoic acid induces RXR homodimer formation: a mechanism defining a novel retinoid pathway
Periodical: Nature Index Medicus:
Authors: Zhang XK, Lehmann JM, Hoffmann B, et al ART
Yr: 1992 Vol: Nbr: Abs: Pg:

Induction of apoptosis by retinoids in human lung cancer cell lines
Periodical: International Journal of Cancer Index Medicus:
Authors: Li Y, Dawson MI, Lee MO, Jong L, Hobbs PD, Zhang XK ART
Yr: 1998 Vol: 75 Nbr: Abs: Pg: 88-95

Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Li Y, Lin B, Agadir A, Liu R, Dawson MI, Reed JC, Zhang XK ART
Yr: 1998 Vol: 18 Nbr: Abs: Pg: 4719-4731

Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Liu R, Takayama S, Zheng Y, et al ART
Yr: 1998 Vol: 273 Nbr: Abs: Pg: 16985-16992

Inhibition of trans-RA-resistant human breast cancer cell growth by retinoid X-receptor-selective retinoids
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Wu Q, Cheng Y, Dawson MI, Hobbs PD, Li Y, Zhang XK ART
Yr: 1997 Vol: 17 Nbr: Abs: Pg: 6598-6608

Activation of three distinct RXR/RAR heterodimers induces growth arrest and differentiation of neuroblastoma cells
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Giannini G, Dawson MI, Zhang XK, Thiele CJ ART
Yr: 1997 Vol: 272 Nbr: Abs: Pg: 26693-26701

Conformationally defined retinoic acid analogs: 4 potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias
Periodical: Journal of Medicinal Chemistry Index Medicus:
Authors: Muccio DD, Brouillette WJ, Breitman TR, et al ART
Yr: 1998 Vol: 41 Nbr: Abs: Pg: 1679-1687

Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 acitivity and retinoic acid-induced apoptosis in human breast cancer cells
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Li Y, Hashimoto Y, Agadir A, Kagechika H, Zhang H-k ART
Yr: 1999 Vol: 274 Nbr: Abs: Pg: 15360-15366

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3
Periodical: Science Index Medicus:
Authors: Li H, Kolluri S, Gu J, et al ART
Yr: 2000 Vol: 289 Nbr: Abs: Pg: 1159-1164

Orphan receptor COUP-TF is required for induction of RARbeta, growth inhibition and apoptosis by retinoic acid in cancer cells
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Lin B, Chen G, Ziao D, et al ART
Yr: 2000 Vol: 20 Nbr: Abs: Pg: 957-970

Unique anti-activator protein-1 activity of retinoic acid receptor beta1
Periodical: Cancer Research Index Medicus:
Authors: Lin F, Ziao D, Kolluri S, Zhang X-K ART
Yr: 2000 Vol: 60 Nbr: Abs: Pg: 3271-3280

Regulation of RARbeta expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction
Periodical: International Journal of Cancer Index Medicus:
Authors: Li Y, Dawson MI, Agadir A, et al ART
Yr: 1998 Vol: 75 Nbr: Abs: Pg: 88-95

Differential effect of retinoic acid on growth regulation by phorbol ester in human cancer cell lines
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Agadir A, Chen GQ, Bost F, Li Y, Mercola D, Zhang X-K ART
Yr: 1999 Vol: 274 Nbr: Abs: Pg: 29779-29785

Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in Lung Cancer Cells.
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Kolluri S, Cao X, Bruey-Sedano N, Lin B, Lin F, Han Y-H, Dawson MI, Zhang XK ART
Yr: 2003 Vol: 23 Nbr: Abs: Pg: 8651-8667

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
Periodical: Cell Index Medicus:
Authors: Lin B, Kolluri S, Cao X, Li H, Han Y-H, Lin F, Reed JC, Zhang X-K ART
Yr: 2004 Vol: 116 Nbr: Abs: Pg: 1-20

Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest.
Periodical: Journal of Medicinal Chemistry Index Medicus:
Authors: Dawson MI, Harris D, Liu G, Hobbs P, Lange C, Jong L, Bruey-Sedano N, James S ART
Yr: 2004 Vol: 47 Nbr: Abs: Pg: 3518 - 3536

Determinants of Retinoid X Receptor transcriptional Antagonism J. Med Chem: 47: 4360-4372.2004
Periodical: Index Medicus:
Authors: Cavasotto, C.N., Liu, G., James S.Y., Hobbs, P.D., Petterson, V. J.,Zhang,X-K ART
Yr: Vol: Nbr: Abs: Pg:

The R-enantiomer of the Non-steroidal Anti-inflammatory Frug Etodolac Binds Retinoid X Receptor and Induces Tumor -selective Apoptosis. PNAS 102:2525-30.2005
Periodical: Index Medicus:
Authors: Kolluri, S.K., Corr, M., James, S.Y., Berasconi, M., Lu, D., Liu, W., Zhang, X-K ART
Yr: Vol: Nbr: Abs: Pg:

Determinants of Retinoid X Receptor Transcriptional Antagonism J Med Chem. 47: 4360-4372.2004
Periodical: Index Medicus:
Authors: Cavasotto, C.N., Liu, G., James. S.Y., Hobbs, P.D., Peterson, V.J., Zhang, X-K., ART
Yr: Vol: Nbr: Abs: Pg:

The R-enantiomer of the Non-steroidal Anti-inflammatory Drug Etodolax Binds Retinoid X Receptor and Induces Tumor -selective Appoptosis PNAS 102 2525-30 2005
Periodical: Index Medicus:
Authors: Zhang X-k ART
Yr: Vol: Nbr: Abs: Pg:

Regulation of nur77 nuclear export by c-Jun N-terminal kinase and akt.
Periodical: Oncogene Index Medicus:
Authors: Han YH, Cao X, Lin B, Lin F, Kolluri SK, Reed JC, Dawson MI, Zhang XK ART
Yr: 2006 Vol: Nbr: Abs: Pg: 1 - 13

Hypericum sampsonni induces apoptosis and nuclear export of retinoid X receptor-alpha
Periodical: Carcinogenesis Index Medicus:
Authors: Zeng JZ, Sun DF, Wang L, Cao X, Qi JB, Yang T, Hu CQ, Liu W, Zhang XK ART
Yr: 2006 Vol: Nbr: Abs: Pg:

A structure-based approach to retinoid X receptor-alpha inhibition
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Stebbins JL, Jung D, Leone M, Zhang XK, Pellecchia M ART
Yr: 2006 Vol: 281 Nbr: Abs: Pg: 16643-16648

Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
Periodical: Oncogene Index Medicus:
Authors: Han YH, Cao X, Lin B, Lin F, Kolluri SK, Stebbins J, Reed JC, Dawson MI, Zhang XK ART
Yr: 2006 Vol: 25 Nbr: Abs: Pg: 2974-2986

Transcription factors that directly target mitochondria for cell death induction
Periodical: Oncogene Index Medicus:
Authors: Moll UM, Marchenko N, Zhang XK ART
Yr: 2006 Vol: 25 Nbr: Abs: Pg: 4725-43

Exploiting the TR3 interaction with Bcl-2 as a novel therapeutic strategy of cancer and leukemia therapy.
Periodical: Blood Index Medicus:
Authors: Zhai, DY, Sergienko, E, Kitada, S, Luciano, F, Satterswaitk AC, Zhang, XK, and Reed, JC ART
Yr: 2006 Vol: 108 Nbr: 80A-80A Abs: Pg: 256 Part 1

A novel peptide containing a nine amino acid sequence from Nur77 induces Bcl-2-dependent apoptosis in AML.
Periodical: Blood Index Medicus:
Authors: Andreeff, M, Konopleva, M, Watt, JC, Samudio, IJ, Satterthwait, AC, Kitada, S, Zhang, XK, ART
Yr: 0 Vol: 108 (11) Nbr: 736A-736A Abs: Pg: 2607 Part 1

Targeting Nur77 Translocation.
Periodical: Expert Opinion on Therapeutic Targets Index Medicus:
Authors: Zhang, XK ART
Yr: 2007 Vol: 11 Nbr: Abs: Pg: 59-79

An adamantyl-substituted retinoid-derived molec that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nucl recptoor: Effects of modifying its carboxylate grp on apoptosis, proliferation, & pro
Periodical: Journal Medical Chemistry Index Medicus:
Authors: Dawson, MI, Xia, ZB, Liu, G, Fontana, JA,Farhana, L, Patel, BB, Arumugarajah, S, Bhuiyan, ART
Yr: 0 Vol: 50 Nbr: 11 Abs: Pg: 2622-2639

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs.
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Bisson,WH, Cheltsov,AV, Bruey-Sedano,N, Lin,B, Chen,J,Goldberger,N, May, LT, Christopoulos ART
Yr: 2007 Vol: 104 Nbr: 29 Abs: Pg: 11927-11932

Nur77 converts phenotype of Bcl-B, an anti-apoptotic protein expressed in plasma cells and myeloma.
Periodical: Blood Index Medicus:
Authors: Luciano,F,Krajewska,M,Ortiz-Rubio,P,Krajewski,S,Zhai,D,Faustin,B,Bruey,JM,Bailly-Maitre,B, ART
Yr: 2007 Vol: 109 Nbr: 9 Abs: Pg: 3849-3855

Nongenomic actions of retinoids:Role of Nur77 and RXR in the regulation of apoptosis and inflammation.
Periodical: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Index Medicus:
Authors: Zeng, JZ, and Zhang, XK ART
Yr: 2007 Vol: 6 Nbr: Abs: Pg: 315-331

RXR agonists inhibits high glucose induced oxidative stress by repressing PKC activity in human endothelial cells.
Periodical: Free Radical Biology and Medicine Index Medicus:
Authors: Chai, D, Wang, B, hen,L, Pn, J, Zhang, XK and He, B ART
Yr: 2008 Vol: 44 Nbr: Abs: Pg: 1334-1347

A short Nur77-derived peptide converts Bcl-2 from a protector to a killer of cancer cells.
Periodical: Index Medicus:
Authors: Kolluri,S,Zhu,X,Zhou,X, Lin B, Chen,Y,Town,J,Cao,X,Lin,F,Zhai,D,Kitada,S,Luciano,F,Reed,JC ART
Yr: Vol: Nbr: Abs: Pg:

Modulation of Nur77-mediated apoptotic pathway by acetylshikonin and analogs
Periodical: Index Medicus:
Authors: Liu,J,Zhou,W,Li,S,Sun,Z,Lin,B,Lang,Y,He,J,Cao,X,Yan,T,Wang,L,Lu,J,Han,Y,Cao,Y,Zhang,X,Zen ART
Yr: Vol: Nbr: Abs: Pg: