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Michael Kelner, M.D., M.S.

University of California, San Diego # of Grants: 6

Grants

Cloning of a Lung Tumor Transport Gene for Drug Development 1995 (Cycle 4) $104,966
Cancer Inno Dev & Exp Awards (IDEAS)

SAR Studies of Novel antitumor Agents for Lung Carcinomas 1995 (Cycle 4) $403,338
Cancer Research Project Awards

Isolation of lung tumor proteins for a novel treatment 1998 (Cycle 7) $75,000
Cancer Inno Dev & Exp Awards (IDEAS)

Studies of novel antitumor agents for lung cancers 1998 (Cycle 7) $306,000
Cancer Research Project Awards

Preclinical Studies of Novel Agents for Lung Cancer 1992 (Cycle 1) $225,000
Cancer New Investigator Awards

Studies of novel antitumor agents for lung carcinoma 2000 (Cycle 9) $833,491
Cancer Research Project Awards
Publications

Preclinical evaluation of illudins as anti-cancer agents: Basis for selective cytotoxicity
Periodical: Journal of the National Cancer Institute Index Medicus:
Authors: Kelner MJ, McMorris TC, Taetle R ART
Yr: 1990 Vol: 82 Nbr: Abs: Pg: 1562-1565

HPLC determination of a new anticancer agent (acylfulvene) in serum
Periodical: Neoplasma Index Medicus:
Authors: Brandsteterova E, Kelner MJ, McMorris TC, Estes L, Bagnell R, Montoya M ART
Yr: 1992 Vol: 39 Nbr: 6 Abs: Pg: 369-373

Structure activity-relationships of illudins: analogs with improved therapeutic index
Periodical: Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, Estes LA, Montoya MM, Taetle R ART
Yr: 1992 Vol: 57 Nbr: 25 Abs: Pg: 6876-6883

HPLC analysis of novel anticancer agents - illudins and their analogs
Periodical: Journal of Liquid Chromatography Index Medicus:
Authors: Brandsteterova E, Kelner MJ, McMorris TC, Wang W, Bagnell R ART
Yr: 1993 Vol: 16 Nbr: 1 Abs: Pg: 115-125

On the mechanism of toxicity of illudins
Periodical: Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, Moon S, Taetle R ART
Yr: 1990 Vol: 3 Nbr: Abs: Pg: 574-579

Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells: unusually high sensitivity of ERCC2 and ERCC3 DNA helicase deficient mutants in comparison to other chemotherapeutic agents
Periodical: Biochemical Pharmacology Index Medicus:
Authors: Kelner MJ, McMorris L, Estes M, et al ART
Yr: 1994 Vol: 48 Nbr: 2 Abs: Pg: 403-409

Nonresponsiveness of the metastatic human lung carcinoma MV522 xenograft to conventional anticancer agents
Periodical: Anticancer Research Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al ART
Yr: 1995 Vol: 15 Nbr: 3 Abs: Pg: 867-872

In vitro and in vivo studies on the anticancer activity of dehydroilludin M
Periodical: Anticancer Research Index Medicus:
Authors: Kelner MJ, McMorris TC, Taetle R ART
Yr: 1995 Vol: 15 Nbr: 3 Abs: Pg: 873-878

Efficacy of Acylfulvene Illudin analogs against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents retention of activity against various phenotypes.
Periodical: Cancer Research Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al ART
Yr: 1995 Vol: 55 Nbr: 21 Abs: Pg: 4936-4940

Acylfulvenes, a new class of potent antitumor agents
Periodical: Experientia Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, Diaz MA, Estes LA, Taetle R ART
Yr: 1996 Vol: 52 Nbr: (1) Abs: Pg: 75-80

Efficacy of HMAF (MGI-114-02) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents
Periodical: Investigational New Drugs Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al ART
Yr: 1996 Vol: 14 Nbr: Abs: Pg: 161-167

Hydroxymethylacylfulvene: an Illudin derivative with superior antitumor properties
Periodical: Journal of Natural Products Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, et al ART
Yr: 1996 Vol: 59 Nbr: Abs: Pg: 896-899

Characterization of cellular accululation and toxicity of Illudin S in sensitive and non-sensitive tumor cells
Periodical: Cancer Chemotherapy and Pharmacology Index Medicus:
Authors: Kelner MJ, McMorris TC, Montoya MA, et al ART
Yr: 1997 Vol: 40 Nbr: Abs: Pg: 65-71

The design and total synthesis of antitumor Acylfulvenes
Periodical: Journal of Organics Chemistry Index Medicus:
Authors: McMorris TC, Yu J, Hi Y, et al ART
Yr: 1997 Vol: 62 Nbr: Abs: Pg: 3015-3018

Characterization of Acylfulvene histiospecific toxicity in human tumor cell lines
Periodical: Cancer Chemotherapy and Pharmacology Index Medicus:
Authors: Kelner MJ, McMorris TC, Montoya MA, et al ART
Yr: 1998 Vol: 41 Nbr: Abs: Pg: 237-242

Reaction of antitumor hydroxymethylacylfulvene (HMAF) with thiols
Periodical: Tetrahedron Letters Index Medicus:
Authors: McMorris TC, Yu J, Estes LA, Kelner MJ ART
Yr: 1997 Vol: 53 Nbr: Abs: Pg: 14579-14590

Efficacy of MGI 114 (6-hydroxymethylfulvene, HMAF)against the mdrI/gp170 Metastatic MV522 lung carcinoma xenograft
Periodical: European Journal of Cancer Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al ART
Yr: 1998 Vol: 34 Nbr: Abs: Pg: 908-913

Metabolism of antitumor Acylfulvene by rat liver cytosol
Periodical: Biochemical Pharmacology Index Medicus:
Authors: McMorris TC, Elayadi AN, Yu J, Kelner MJ ART
Yr: 1999 Vol: 57 Nbr: Abs: Pg: 83-88

Characterization of MGI 114 (HMAF): Histiospecific toxicity in human tumor cell lines
Periodical: Cancer Chemotherapy and Pharmacology Index Medicus:
Authors: Kelner MJ, McMorris TC, Montoya MA, et al ART
Yr: 1999 Vol: Nbr: Abs: Pg:

Metabolism of antitumor MGI 114 (HMAF) rat liver cytosol
Periodical: Drug Metabolism and Disposition Index Medicus:
Authors: McMorris TC, Elayadi AN, Yu J, Hu Y, Kelner MJ ART
Yr: 1999 Vol: Nbr: Abs: Pg:

Efficacy of MGIII 114 against the MRP-positive metastatic MV522 lung carcinoma xenograft
Periodical: Anti-cancer Drugs Index Medicus:
Authors: Kelner, MJ, McMorris TC, Estes MY, et al ART
Yr: 2000 Vol: 11 Nbr: Abs: Pg: 217-224

Anti-leukemic action of the novel agent MGI 114 HMAF and synergistic action with Topotecan
Periodical: Leukemia Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes KM, et al ART
Yr: 2000 Vol: 14 Nbr: Abs: Pg: 136-141

Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and related analogues.
Periodical: Journal of Organics Chemistry Index Medicus:
Authors: McMorris TC, Yu J, Lira R, Dawe R, MacDonald JR, and Kelner MJ ART
Yr: 2001 Vol: 6 Nbr: Abs: Pg: 6158 - 6163

Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C.
Periodical: Cancer Chemotherapy and Pharmacology Index Medicus:
Authors: Kelner MJ, McMorris TC, Rojas RJ, Trani NA and Estes I ART
Yr: 2002 Vol: 49 Nbr: Abs: Pg: 412-418

Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with Topotecan.
Periodical: Leukemia Index Medicus:
Authors: Kelner M, McMorris TC, Estes L, Samson KM, Trani NA, MacDonald JR ART
Yr: 2000 Vol: 14 Nbr: Abs: Pg: 136-141

Efficacy of MGI 114 against the MRP-positive metastatic MV522 lung carcinoma xenograft.
Periodical: Anti-cancer Drugs Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes LA, Oval MY, Rojas RJ, Lynn JR, Lanham KA, Samson KM. ART
Yr: 2000 Vol: 11 Nbr: Abs: Pg: 217-224

Preparation and biological activity of amino acid and peptide conjugates of antitumor hyroxylmethylacylfulvene.
Periodical: Journal of Medicinal Chemistry Index Medicus:
Authors: McMorris TC, Yu J, Ngo HT, Wang H, Kelner MJ ART
Yr: 2000 Vol: 43 Nbr: Abs: Pg: 3577-3580

Sequiterpenes from the basidiomycete omphalotus illudens.
Periodical: Journal of Natural Products Index Medicus:
Authors: McMorris TC, Lira R, Gantzel PK, Kelner MJ, Dawe R ART
Yr: 2000 Vol: 63 Nbr: Abs: Pg: 1557-1559

Structure-activity studies of antitumor agent irofulven (HMAF) and related analogues.
Periodical: Journal of Organics Chemistry Index Medicus:
Authors: McMorris TC, Yu J, Lira R, Dawe R, MacDonald JR, Kelner MJ ART
Yr: 2001 Vol: 6 Nbr: Abs: Pg: 6158-6163

Enhanced antitumor activity of irofulven in combination with antimitotics.
Periodical: Investigational New Drugs Index Medicus:
Authors: Kelner MJ, McMorris TC, Rojas RJ, Trani NA, Estes L ART
Yr: 2002 Vol: 20 Nbr: Abs: Pg: 267-279

Sesquiterpenes from omphalotus illudens
Periodical: Phytochemistry Index Medicus:
Authors: McMorris, Kashinatham A, Lira R, Rundgren H, Gantzel PK, Kelner MJ, Dawes R ART
Yr: 2002 Vol: 61 Nbr: Abs: Pg: 395-398

Genotoxic action of anti-tumor illudin compounds including irufulven.
Periodical: DNA Repair Index Medicus:
Authors: Jaspers NGJ, Raams A, Kelner MJ, Ng J, Takeda S, McMorris, Hoeijmakers JHJ ART
Yr: 2002 Vol: 11 Nbr: Abs: Pg: 1027-1038

Reaction of irofulven with zinc and acid
Periodical: Journal of Natural Products Index Medicus:
Authors: McMorris TC, Moon S, Kelner MJ ART
Yr: 2003 Vol: 66 Nbr: Abs: Pg: 310-312