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Henry Lester, Ph.D.

California Institute of Technology # of Grants: 8

Grants

-Heterologous Expression of Brain Nicotinic Acetylcholine Re 1995 (Cycle 4) $598,774
Nicotine Dependence Research Project Awards

Hyperactive nicotine receptors 1997 (Cycle 6) $486,158
Nicotine Dependence Research Project Awards

Heterologous Expression of Brain Nicotinic Receptors 1992 (Cycle 1) $586,840
Nicotine Dependence Research Project Awards

Hyperactive nicotine receptors 2000 (Cycle 9) $1,138,225
Nicotine Dependence Research Project Awards

Hyperactive nicotine receptors 2003 (Cycle 12) $675,487
Nicotine Dependence Research Project Awards

Nicotinic receptors in nicotine addiction 2008 (Cycle 17) $634,743
Nicotine Dependence Research Project Awards

Nicotine Receptor in Nicotine Dependence 2011 (Cycle 20) $404,642
Nicotine Dependence Exploratory/Developmental Award

Subcellular pharmacokinetics of nicotinic compounds 2014 (Cycle 23) $316,350
Disparities /Prevention/ Cessation/ Nicotine Dependence Exploratory/Developmental Award
Publications

TRIS+ NA+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region
Periodical: Journal of General Physiology Index Medicus:
Authors: Cohen BN, Labarca C, Czyzyk L, Davidson N, Lester HA ART
Yr: 1992 Vol: 99 Nbr: Abs: Pg: 545-572

Pharmacological and kinetic properties of alpha4beta2 neuronal nicotinic acetylcholine receports expressed in Xenopus oocytes
Periodical: Index Medicus:
Authors: Charnet P, Labarca C, Cohen BC, Davidson N, Lester HA, Pilar G ART
Yr: 1992 Vol: 450 Nbr: Abs: Pg: 375-394

Structure of the gamma-less nicotinic acetylcholine receptor: learning from omission
Periodical: Molecular Pharmacology Index Medicus:
Authors: Charnet P, Labarca C, Lester HA ART
Yr: 1992 Vol: 41 Nbr: 4 Abs: Pg: 708-717

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and for alkali metal cations
Periodical: Journal of General Physiology Index Medicus:
Authors: Cohen BN, Labarca C, Davidson N, Lester HA ART
Yr: 1992 Vol: 100 Nbr: 3 Abs: Pg: 373-400

Regions of beta4.beta2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors
Periodical: FEBS Journal Index Medicus:
Authors: Figl A, Cohen BN, Quick MW, Davidson N, Lester HA ART
Yr: 1992 Vol: 308 Nbr: 3 Abs: Pg: 245-248

The permeation pathway of neurotransmitter-gated ion channels
Periodical: Annual Review of Biophysics and Biomolecular Structure Index Medicus:
Authors: Lester HA ART
Yr: 1992 Vol: 21 Nbr: Abs: Pg: 267-292

Regions of beta-2 and beta-4 responsible for differences between the equilibrium dose-response relationships of the alpha3beta2 and alpha3beta4 neuronal nicotinic receptors
Periodical: Journal of General Physiology Index Medicus:
Authors: Cohen BN, Figl A, Quick M, Labarca C, Davidson N, Lester HA ART
Yr: 0 Vol: Nbr: Abs: Pg:

Nicotinic receptor binding site probed with unnatural amino-acid incorporation in intact cells
Periodical: Science Index Medicus:
Authors: Nowak MW, Kearney PC, Sampson JR, et al ART
Yr: 1995 Vol: 268 Nbr: 5209 Abs: Pg: 439-442

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic recptors
Periodical: Nature Index Medicus:
Authors: Labarca C, Nowak M, Zhang H, Tang L, Deshpande P, Lester HA ART
Yr: 1995 Vol: 376 Nbr: 6540 Abs: Pg: 514-516

Voltage-jump relaxation kinetics for wild type and chimeric beta subunits of neuronal nicotinic receptors
Periodical: Journal of General Physiology Index Medicus:
Authors: Figl A, Labarca C, Davidson N, Lester HA, Cohen BN ART
Yr: 1996 Vol: 107 Nbr: 3 Abs: Pg: 369-379

Regions of beta2 and beta4 responsible for differences between the equilibrium dose-response relatioships of the alpha3beta2 and alpha3beta4 neuronal nicotinic receptors
Periodical: Journal of General Physiology Index Medicus:
Authors: Cohen BN, Figl A, Quick MW, Labarca C, Davidson N, Lester HA ART
Yr: 0 Vol: Article in Nbr: Press Abs: Pg:

Site-specific, photochemical proteolysis applied to ion channels In Vivo
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: England P, Lester HA, Davidson N, Dougherty DA ART
Yr: 1997 Vol: 94 Nbr: Abs: Pg: 11025-11030

Expression and circular dichroism studies of the extracellular domain of the alpha subunit of the nicotinic acetylcholine receptor
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: West AP, Bjorkman PJ, Dougherty DA, Lester HA ART
Yr: 1997 Vol: 272 Nbr: Abs: Pg: 25468-25473

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, Dougherty DA ART
Yr: 1998 Vol: Nbr: Abs: Pg:

From ab initio quantum mechanics to molecular neurobiology: A cation- binding site in the nicotinic receptor
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, Dougherty DA ART
Yr: 1998 Vol: 95 Nbr: Abs: Pg: 12088-12095

Point mutant mice with hypersensitive a4 nicotinic receptors show dopaminergic deficits and increased anxiety
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Labarca C, Schwarz J, Deshpande P, et al ART
Yr: 2001 Vol: 98 Nbr: Abs: Pg: 2786-2791

Point mutant mice with hypersensitive alpha4 nicotinic receptors show dopaminergic deficits and increased anxiety
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Labarca C, Schwarz J, Deshpande P, et al ART
Yr: 98 Vol: Nbr: Abs: Pg: 2786-2791

Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nivotinic receptors.
Periodical: Journal of Neuroscience Index Medicus:
Authors: Fonck C, Nashmi R, Deshpande P, Damaj M, Riedel A, Schwarz J, Collins A, et.al ART
Yr: 2003 Vol: 23 Nbr: 7 Abs: Pg: 2582-2590

Alpha4Beta2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response targets for both nicotine and ethanol.
Periodical: Alcoholism: Clinical and Experimental Research Index Medicus:
Authors: Owens JC, Balogh SA, McClure-Begley TD, Butt CM, Mabarca C, Lester HA, et.al ART
Yr: 2003 Vol: 27 Nbr: Abs: Pg: 1867-75

Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: Effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.
Periodical: Journal of Neuroscience Index Medicus:
Authors: Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA ART
Yr: 2003 Vol: 23 Nbr: Abs: Pg: 11554-11567

Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: Effects of localization, trafficking and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.
Periodical: Journal of Neuroscience Index Medicus:
Authors: Lester HA, Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE ART
Yr: 2003 Vol: 23 Nbr: Abs: Pg: 11554-11567

An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with FRET and TIRF microscopy.
Periodical: Journal of Neuroscience Index Medicus:
Authors: Khakh BS, Fisher JA, Nashmi R, Bowser DN, Lester HA ART
Yr: 2005 Vol: 25 Nbr: Abs: Pg: 6911 - 6920

Nicotine action on alpha4* receptors: sufficiennt for reward, tolerance and sensitization.
Periodical: Science Index Medicus:
Authors: Tapper A, McKinney S, Nashmi R, Schwarz J, Lester H, et al. ART
Yr: 2004 Vol: 306 Nbr: Abs: Pg: 1029 - 1032

Nicotine action on a4 receptors: sufficient for reward, tolerance and sensitization science
Periodical: Science Index Medicus:
Authors: Tapper A, McKinney S, Nashmi R, Schwarz J, Deshapande P, Labarca C, Whiteaker P, Collins ART
Yr: 2004 Vol: Nbr: 306 Abs: Pg: 1029-1032

Novel seizure phenotyphe and sleep disruptions in Knock-in mice with hypersensitive a4 nicotinic receptors
Periodical: Journal of Neuroscience Index Medicus:
Authors: Fonck C, Cohen BN, Nashmi R, Whiteaker P, Wagenaar D, Rodrigues-Pinguet N, Deshpande P, ART
Yr: 2005 Vol: Nbr: 25:49 Abs: Pg: 11396-11411

An angstrom scale interaction between plasma membrane ATP-gated P2X2 and a4B2 nicotine channels measured with FRET and TIRF microscopy
Periodical: Journal of Neuroscience Index Medicus:
Authors: Khakh BS, Fisher JA, Nashmi R, Bowser DN and Lester HA ART
Yr: 2005 Vol: 25 Nbr: Abs: Pg: 6911-6920

The prototoxin lynx 1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival
Periodical: Neuron Index Medicus:
Authors: Miwa, J., Stevens T., King S, Caldarone B., Ibanez-Tallon, I., Xiao, C., Fitzsimonds, R. ART
Yr: 2006 Vol: Nbr: 51 Abs: Pg: 1-14

Enhanced expression of hypersensitive a4 nAChR in adult mice increases the loss of midbrain dopaminergic neurons
Periodical: FASEB Journal Index Medicus:
Authors: Schwarz, J., Schwarz S., Dorigo, O., Stutzer, A., Wegner, F., Labarca, C., Deshpande, P., ART
Yr: 2006 Vol: Nbr: 20 Abs: Pg: 935-946

In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity a6* Nicotinic Acetycholine Receptors.
Periodical: Neuron Index Medicus:
Authors: Drenan, RM, Grady, SR. Whiteaker, P, McClure-Begley, T, McKinney, SJ, Miwa, JM, Bupp, S, ART
Yr: 2008 Vol: 60 Nbr: 1 Abs: Pg: 123-36

Chronic nicotine selectively enhances a4B2 nicotinic acetycholine receptors in the nigrostriatal dopamine pathway
Periodical: Journal of Neuroscience Index Medicus:
Authors: Xiao, C, Nashmi, R, McKinney, S, Cai, H, McIntosh, JM, Lester, HA ART
Yr: 2009 Vol: Nbr: Abs: Pg:

Nicotine upregulates a4B2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning
Periodical: Journal of General Physiology Index Medicus:
Authors: Srinivasan R, Pantoja R, Moss FJ, Mackey EDW, Son C, Miwa J, and Lester HA ART
Yr: 2011 Vol: Nbr: 137 Abs: Pg: 59-79

Characterizing functional a6B2 nicotinic acetylcholine receptors in vitro: mutant B2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells
Periodical: Biochemical Pharmacology Index Medicus:
Authors: Xiao C, Srinivasan R, Drenan RM, Mackey ED, Mcintosh JM, and Lester HA ART
Yr: 2011 Vol: Nbr: 82 Abs: Pg: 852-61

Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations.
Periodical: Pharmacological Reviews Index Medicus:
Authors: Drenan RM, and Lester HA ART
Yr: 2012 Vol: Nbr: Abs: Pg: PMID 22885704

Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic_x000d_ Pathways: Therapeutic Effects
Periodical: Biological Psychiatry Index Medicus:
Authors: Lester HA, Miwa JM, and Srinivasan R ART
Yr: 2012 Vol: Nbr: Abs: Pg: PMID 22771239

a6* Nicotinic Acetylcholine Receptor Expression and Function in a_x000d_ Visual Salience Circuit
Periodical: Journal of Neuroscience Index Medicus:
Authors: Mackey ED, Engle SE, Kim MR, O'Neill HC, Wageman CR, Patzlaff NE, Wang Y, Grady SR, Mcinto ART
Yr: 2012 Vol: Nbr: 32 Abs: Pg: 10226-37

Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures
Periodical: Nano Letters Index Medicus:
Authors: Richards CI, Luong K, Srinivasan R, Turner SW, Dougherty DA, Korlach J, and Lester HA ART
Yr: 2012 Vol: Nbr: 12 Abs: Pg: 11474-80

Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the ER stress response
Periodical: Molecular Pharmacology Index Medicus:
Authors: Srinivasan R, Richards CI, Xiao C, Rhee D, Pantoja R, Dougherty DA, Miwa JM, and Lester HA ART
Yr: 2012 Vol: Nbr: 81 Abs: Pg: 759-69

Transcriptional regulation by nicotine in dopaminergic neurons
Periodical: Index Medicus:
Authors: Hanley BM, Williams BA, Srinivasan R, Cohen BN, Xiao C, Mackey ED, Wold BJ and Lester HA ART
Yr: Vol: Nbr: Abs: Pg:

Menthol alone upregulates midbrain nAChRs, alters nAChR subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward
Periodical: Index Medicus:
Authors: Henderson B, Wall T, Henley BM, Kim C, Nichols W, Moaddel R, Xiao C, Lester H ART
Yr: Vol: Nbr: Abs: Pg: